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Article

Mutational spectrum of CENP-B box and α-satellite DNA on chromosome 21 in Down syndrome children.

Molecular medicine reports - 1 Apr 2017

Chen Qian, Tan Bin, He Jun-Lin, Liu Xue-Qing, Chen Xue-Mei, Gao Ru-Fei, Zhu Jing, Wang Ying-Xiong, Qi Hong-Bo

Abstract excerpt

The centromere is responsible for the correct inheritance of eukaryotic chromosomes during cell division. Centromere protein B (CENP‑B) and its 17 base pair binding site (CENP‑B box), which appears at regular intervals in centromeric α-satellite DNA (α-satDNA), are important for the assembly of the centromere components. Therefore, it is conceivable that CENP-B box mutations may induce errors in cell division....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28259924
DOI: 10.3892/mmr.2017.6247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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