Characterization of flaA- and flaB- mutants of Serpulina hyodysenteriae: both flagellin subunits, FlaA and FlaB, are necessary for full motility and intestinal colonization.

Abstract excerpt

Motility of Serpulina hyodysenterlae is thought to play a pivotal role in the enteropathogenicity of this spirochete. To test this, a series of isogenic mutants containing specifically disrupted flagellar alleles (flaA1 and flaB1) were constructed and examined for virulence and ability to colonize the intestinal tract of mice. Mice challenged with the wild-type, parent strain showed a dose-related response to the...

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