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Article

FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath.

Infection and immunity - 1 Jun 2012

Lambert Ambroise, Picardeau Mathieu, Haake David A, Sermswan Rasana W, Srikram Amporn, Adler Ben, Murray Gerald A

Abstract excerpt

Spirochetes have periplasmic flagella composed of a core surrounded by a sheath. The pathogen Leptospira interrogans has four flaB (proposed core subunit) and two flaA (proposed sheath subunit) genes. The flaA genes are organized in a locus with flaA2 immediately upstream of flaA1. In this study, flaA1 and flaA2 mutants were constructed by transposon mutagenesis. Both mutants still produced periplasmic flagella....

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Identifiers

PMID: 22451522
DOI: 10.1128/IAI.00131-12
PMCID: PMC3370569

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