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Article

Identification of somatic mutations in parathyroid tumors using whole-exome sequencing.

The Journal of clinical endocrinology and metabolism - 1 Sept 2012

Cromer M Kyle, Starker Lee F, Choi Murim, Udelsman Robert, Nelson-Williams Carol, Lifton Richard P, Carling Tobias

Abstract excerpt

CONTEXT: The underlying molecular alterations causing sporadic parathyroid adenomas that drive primary hyperparathyroidism have not been thoroughly defined. OBJECTIVE: The aim of the study was to investigate the occurrence of somatic mutations driving tumor formation and progression in sporadic parathyroid adenoma using whole-exome sequencing. DESIGN: Eight matched tumor-constitutional DNA pairs from patients...

Topics

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Adenoma
Cohort Studies
DNA, Neoplasm
Enhancer of Zeste Homolog 2 Protein
Multiple Endocrine Neoplasia Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parathyroid Neoplasms

Polycomb Repressive Complex 2

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 22740705
DOI: 10.1210/jc.2012-1743
PMCID: PMC5393442

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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