Article
Nuclear structural conditions and PCR amplification in human preimplantation diagnosis.
Molecular human reproduction - 1 Jan 1996
Cui K H, Matthews C D
Abstract excerpt
An understanding of the relationship between nuclear morphology and DNA function is important in cytology and preimplantation diagnosis. In this study, direct polymerase chain reaction (PCR) amplification was used to diagnose the common delta F508 mutation of cystic fibrosis in 62 biopsied human embryo cells. The nuclei were photographed and classified into three categories depending on their microscopic...
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