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Article

DNA damage and metabolic activity in the preimplantation embryo

4 Oct 2008

Abstract excerpt

BACKGROUND: Embryos with greater viability have a lower or 'quieter' amino acid metabolism than those which arrest. We have hypothesized this is due to non-viable embryos possessing greater cellular/molecular damage and consuming more nutrients, such as amino acids for repair processes. We have tested this proposition by measuring physical damage to DNA in bovine, porcine and human embryos at the blastocyst stage...

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PMID: 18835872
DOI: 10.1093/humrep/den346

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