Article
In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Jun 1997
Cornelius J G, Tchernev V, Kao K J, Peck A B
Abstract excerpt
Pancreatic islets of Langerhans exhibit an architecture and cellular organization ideal for rapid, yet finely controlled, responses to changes in blood glucose levels. In type I, insulin-dependent diabetes (IDD), this organization is lost as a result of the progressive autoimmune response which selectively destroys the insulin-producing pancreatic beta cells. Since beta cells are perceived as end-stage...
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