Article
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.
The Journal of biological chemistry - 25 Jul 1997
Saftig P, Hartmann D, Lüllmann-Rauch R, Wolff J, Evers M, Köster A, Hetman M, von Figura K, Peters C
Abstract excerpt
Lysosomal acid phosphatase (LAP) is a tartrate-sensitive enzyme with ubiquitous expression. Neither the physiological substrates nor the functional significance is known. Mice with a deficiency of LAP generated by targeted disruption of the LAP gene are fertile and develop normally. Microscopic e...
Topics
- Acid Phosphatase
- Animals
- Antigens, CD
- Bone and Bones
- Cathepsin D
- Central Nervous System Diseases
- Fibroblasts
- Kidney Diseases
- Lysosomal Storage Diseases
- Lysosomal Membrane Proteins
- Lysosomes
- Membrane Glycoproteins
- Mice
- Microglia
- Phenotype
- Seizures
- Tartrates