Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice).

doi:10.1007/s004010050857

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Article

Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice).

Acta neuropathologica - 1 Jul 1998

Oya Y, Nakayasu H, Fujita N, Suzuki K, Suzuki K

Abstract excerpt

Sphingolipid activator proteins (SAPs) A to D are lysosomal factors required in degradation of sphingolipids with short hydrophilic head groups and are derived from a precursor protein. Sap-B deficiency causes a variant of metachromatic leukodystrophy and sap-C deficiency causes a variant of Gauc...

Topics

Animals
Axons
Brain
Glycoproteins
Humans
Mice
Mice, Knockout
Microscopy, Electron
Muscle, Skeletal
Nervous System
Neuroglia
Neurons
Peripheral Nerves
Phenotype
Saposins
Spheroids, Cellular
Sphingolipid Activator Proteins
Time Factors

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