Article
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.
Chemistry & biology - 1 Aug 2001
Kwok B H, Koh B, Ndubuisi M I, Elofsson M, Crews C M
Abstract excerpt
BACKGROUND: Biologically active natural products continue to be useful in the exploration and control of intracellular signaling processes. For example, the sesquiterpene lactone parthenolide from the anti-inflammatory medicinal herb Feverfew (Tanacetum parthenium) appears to inhibit the pro-inflammatory signaling pathway. Parthenolide's direct molecular target, however, remains unknown. We set out to identify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.