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Thyroid Hormone Receptor Gene Expression in First Trimester Human Fetal Brain

1 Jul 2000

Abstract excerpt

Maternal thyroid hormone is transferred to the fetus early in pregnancy and is postulated to regulate brain development. Thyroid hormone nuclear receptor (TR) proteins are present in fetal brain, but their isoformal composition is unknown. We therefore investigated the ontogeny of TR isoforms and related splice variants in first trimester human fetal brain (n = 9) by semi-quantitative reverse...

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PMID: 10902817
DOI: 10.1210/jcem.85.7.6766

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