Article
Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism.
Brain research - 6 Jun 1997
Yamamoto M, Kondo I, Ogawa N, Asanuma M, Yamashita Y, Mizuno Y
Abstract excerpt
The apolipoprotein E (ApoE*) gene is a major risk factor of developing Alzheimer's disease (AD) and the alpha1-antichymotrypsin (ACT) polymorphism is likely to modify susceptibility of the ApoE* gene for AD. Because pathogenesis of AD is partly similar to that in idiopathic Parkinson's disease (PD), we investigated the distribution of genotypes of the ApoE and the ACT in patients with PD. The number of...
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