Article
Deregulation of CLN1 and CLN2 in the Saccharomyces cerevisiae whi2 mutant.
Yeast (Chichester, England) - 30 Jun 1997
Radcliffe P, Trevethick J, Tyers M, Sudbery P
Abstract excerpt
Wild-type cells of the budding yeast Saccharbmyces cerevisiae arrest in G1 upon nutrient exhaustion. Cell cycle arrest requires the WHI2 gene since whi2 mutants continue to divide and become abnormally small as nutrients are depleted. Here we show that CLN1 and CLN2 transcript levels in a whi2 strain are higher during exponential growth, and persist longer upon starvation, than in an isogenic wild-type strain. In...
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