Article
Carboxylesterase-mediated insecticide resistance: Quantitative increase induces broader metabolic resistance than qualitative change.
Pesticide biochemistry and physiology - 1 Jun 2015
Cui Feng, Li Mei-Xia, Chang Hai-Jing, Mao Yun, Zhang Han-Ying, Lu Li-Xia, Yan Shuai-Guo, Lang Ming-Lin, Liu Li, Qiao Chuan-Ling
Abstract excerpt
Carboxylesterases are mainly involved in the mediation of metabolic resistance of many insects to organophosphate (OP) insecticides. Carboxylesterases underwent two divergent evolutionary events: (1) quantitative mechanism characterized by the overproduction of carboxylesterase protein; and (2) qualitative mechanism caused by changes in enzymatic properties because of mutation from glycine/alanine to aspartate at...
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