Article
Two single mutations commonly cause qualitative change of nonspecific carboxylesterases in insects.
Insect biochemistry and molecular biology - 1 Jan 2011
Cui Feng, Lin Zhe, Wang Hongsheng, Liu Silu, Chang Haijing, Reeck Gerald, Qiao Chuanling, Raymond Michel, Kang Le
Abstract excerpt
Carboxylesterases provide key mechanisms of resistance to insecticides, particularly organophosphates (OPs), in insects. One resistance mechanism is a qualitative change in the properties of a carboxylesterase. Two mutant forms, G151D and W271L, have been observed, mostly in dipteran species, to affect substrate specificity of enzymes. But whether these two single mutations can commonly change character of insect...
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