CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice.

Abstract excerpt

Autoimmune diseases result from a failure of tolerance. Although many self-reactive T cells are present in animals and humans, their activation appears to be prevented normally by regulatory T cells. In this study, we show that regulatory CD4(+) T cells do protect mice against the spontaneous occ...

Topics

• Animals
• CD4-Positive T-Lymphocytes
• Disease Models, Animal
• Encephalomyelitis, Autoimmune, Experimental
• Flow Cytometry
• Mice
• Mice, Knockout
• Multiple Sclerosis
• Myelin Basic Protein
• Phenotype
• Receptors, Antigen, T-Cell
• Thymus Gland