Article
Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells.
Oncogene - 19 Jun 1997
Zhang H T, Zhang X, Zhao H Z, Kajino Y, Weber B L, Davis J G, Wang Q, O'Rourke D M, Zhang H B, Kajino K, Greene M I
Abstract excerpt
We have analysed the relationship of the products of two genes, neu and BRCA1, known to be important in human breast cancer. Highly specific antibodies that recognized both the rodent and human form of the BRCA1 gene product (Mr 215 kDa, p215BRCA1) were developed to facilitate these efforts. p215BRCA1 was identified as a tyrosine phosphorylated protein primarily localized in the nucleus of several breast cancer...
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