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Retroviral Insertional Mutagenesis of a Herpesvirus: A Marek's Disease Virus Mutant Attenuated for Oncogenicity but Not for Immunosuppression or in vivo Replication

1 Apr 1997

Abstract excerpt

Our earlier studies have shown that retrovirus insertion into herpesvirus is an efficient process that engenders recombinant herpesviruses with altered biological properties. The RM1 clone is derived from the JM strain of Marek's disease virus (MDV) through retrovirus insertional mutagenesis and contains sequences of reticuloendotheliosis virus inserted at the junction of the internal repeat and unique short...

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PMID: 9201407
DOI: 10.2307/1592197

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