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Article

Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity.

Virology journal - 30 Jan 2008

Zhao Yuguang, Petherbridge Lawrence, Smith Lorraine P, Baigent Sue, Nair Venugopal

Abstract excerpt

Cloning of full length genomes of herpesviruses as bacterial artificial chromosomes (BAC) has greatly facilitated the manipulation of the genomes of several herpesviruses to identify the pathogenic determinants. We have previously reported the construction of the BAC clone (pRB-1B5) of the highly oncogenic Marek's disease virus (MDV) strain RB-1B, which has proven to be a valuable resource for elucidating several...

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Identifiers

PMID: 18230192
DOI: 10.1186/1743-422X-5-19
PMCID: PMC2248170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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