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Serotype 1 Viruses Modified by Backpassage or Insertional Mutagenesis: Approaching the Threshold of Vaccine Efficacy in Marek's Disease

1 Dec 2004

Abstract excerpt

Improved vaccines to control Marek's disease (MD) in chickens are desired by the poultry industry but have been difficult to develop. Studies were conducted to evaluate strategies for deriving MD vaccines of high protective efficacy, irrespective of virulence. Candidate viruses from parent strains representing v and vv+ pathotypes were modified by cell culture passage, backpassage in chickens, or insertional...

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PMID: 15666858
DOI: 10.1637/7203-050304r

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