A Marek's Disease Virus vIL-8 Deletion Mutant Has Attenuated Virulence and Confers Protection Against Challenge with a Very Virulent Plus Strain

doi:10.1637/7277-091004

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A Marek's Disease Virus vIL-8 Deletion Mutant Has Attenuated Virulence and Confers Protection Against Challenge with a Very Virulent Plus Strain

1 Jun 2005

Abstract excerpt

Marek's disease virus (MDV) is an alpha-herpesvirus that causes rapid development of T-cell lymphomas in chickens. MDV-encoded vIL-8 is homologous to the cellular IL-8 gene, and its function in MDV pathogenesis has yet to be determined. Using overlapping cosmid clone-based technology, we have generated an MDV vIL-8 deletion mutant virus, rMd5/delta vIL-8. In vivo experiments with this mutant virus demonstrated...

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PMID: 16094823
DOI: 10.1637/7277-091004

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