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Oncogenicity of Virulent Marek's Disease Virus Cloned as Bacterial Artificial Chromosomes

12 Nov 2004

Abstract excerpt

Marek's disease virus (MDV) is an oncogenic alphaherpesvirus that induces T-cell lymphomas in poultry. We report the construction of bacterial artificial chromosome (BAC) clones of the highly oncogenic RB-1B strain by inserting mini-F vector sequences into the U(S)2 locus. MDV reconstituted from two BAC clones induced rapid-onset lymphomas similar to those induced by the wild-type virus. Virus reconstituted from...

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PMID: 15542691
DOI: 10.1128/jvi.78.23.13376-13380.2004

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