Article
Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 1997
Hegele R A, Connelly P W, Hanley A J, Sun F, Harris S B, Zinman B
Abstract excerpt
We hypothesized that common genomic variants would be associated with variation in lipoprotein phenotypes in young subjects. We determined genotypes of FABP2, PON, APOC3, and APOE in 188 aboriginal Canadians, aged 9 to 17 years. We found that 13 of 32 possible genotype-phenotype associations were significant: (1) the FABP2 codon 54 genotype was associated with variation in plasma triglycerides (P = .045); (2) the...
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