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Article

General formulas for obtaining the MLEs and the asymptotic variance-covariance matrix in mapping quantitative trait loci when using the EM algorithm.

Biometrics - 1 Jun 1997

Kao C H, Zeng Z B

Abstract excerpt

We present in this paper general formulas for deriving the maximum likelihood estimates and the asymptotic variance-covariance matrix of the positions and effects of quantitative trait loci (QTLs) in a finite normal mixture model when the EM algorithm is used for mapping QTLs. The general formulas are based on two matrices D and Q, where D is the genetic design matrix, characterizing the genetic effects of the...

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PMID: 9192455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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