Article
Cytoreductive effects of farnesyl transferase inhibitors on multiple myeloma tumor cells.
Molecular cancer therapeutics - 1 Jun 2003
Shi Yijiang, Gera Joseph, Hsu Jung-Hsin, Van Ness Brian, Lichtenstein Alan
Abstract excerpt
Farnesyl transferase inhibitors (FTIs) are anticancer agents designed to target ras processing and ras-dependent signal pathways. Because oncogenic ras mutations are found in up to 50% of multiple myeloma (MM) specimens, these agents may be effective in this disease. However, some preclinical studies suggest that FTI antitumor responses are unrelated to effects on ras. To address this issue in myeloma, we used...
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