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Article

Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.

The Journal of steroid biochemistry and molecular biology - 1 Jan 1997

Kurebayashi S, Miyashita Y, Hirose T, Kasayama S, Akira S, Kishimoto T

Abstract excerpt

Estrogens are the most effective agents available for preventing osteoporosis, and their principal role in bone metabolism is the inhibition of interleukin-6 (IL-6) production in osteoblasts and bone marrow stromal cells. We examined the mechanism of inhibitory effect of estrogens on the 190 bp proximal promoter of the IL-6 gene. Promoter activity induced by transfection of both NF-kappaB p65 subunit and NF-IL6...

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PMID: 9182853
DOI: 10.1016/s0960-0760(96)00175-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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