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Article

IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6

1 Sept 1996

Abstract excerpt

IL-4 alone or in cooperation with LPS can induce the expression of the gene encoding the secreted-type IL-1 receptor antagonist (sIL-1ra) in mononuclear phagocytes. To determine the nuclear signaling mechanisms involved in this response, the region flanking the transcription start site of the human sIL-1ra gene was placed upstream of the luciferase reporter gene, and the function of specific sequence elements was...

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PMID: 8757327
DOI: 10.4049/jimmunol.157.5.2058

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