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Article

Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.

Genetics - 1 Jun 1997

Boube M, Benassayag C, Seroude L, Cribbs D L

Abstract excerpt

Mutations of the Drosophila homeotic proboscipedia gene (pb, the Hox-A2/B2 homologue) provoke dose-sensitive defects. These were used to search for dose-sensitive dominant modifiers of pb function. Two identified interacting genes were the proto-oncogene Ras1 and its functional antagonist Gap1, prominent intermediaries in known signal transduction pathways. Ras1+ is a positive modifier of pb activity both in...

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Identifiers

PMID: 9178011
DOI: 10.1093/genetics/146.2.619
PMCID: PMC1208002

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