Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.

doi:10.1093/genetics/146.2.619

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Article

Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.

Genetics - 1 Jun 1997

Boube M, Benassayag C, Seroude L, Cribbs D L

Abstract excerpt

Mutations of the Drosophila homeotic proboscipedia gene (pb, the Hox-A2/B2 homologue) provoke dose-sensitive defects. These were used to search for dose-sensitive dominant modifiers of pb function. Two identified interacting genes were the proto-oncogene Ras1 and its functional antagonist Gap1, prominent intermediaries in known signal transduction pathways. Ras1+ is a positive modifier of pb activity both in...

Topics

Animals
Animals, Genetically Modified
Body Patterning
Drosophila melanogaster
GTPase-Activating Proteins
Gene Expression Regulation, Developmental
Genes, Homeobox
Genes, Insect
Genes, ras
In Situ Hybridization
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Proteins

Signal Transduction

Transcription, Genetic

ras GTPase-Activating Proteins

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9178011
DOI: 10.1093/genetics/146.2.619
PMCID: PMC1208002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9178011-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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