Article
Plectin transcript diversity: identification and tissue distribution of variants with distinct first coding exons and rodless isoforms.
Genomics - 15 May 1997
Elliott C E, Becker B, Oehler S, Castañón M J, Hauptmann R, Wiche G
Abstract excerpt
Plectin is a widely expressed protein that is very large in size and that has all the attributes of a multifunctional crosslinking and organizing element of the cytoskeleton. It displays a multidomain structure, versatile binding activities, and subcellular localizations that enable it to strengthen cells against mechanical stress forces. Moreover, hereditary gene defects in plectin cause epidermolysis bullosa...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- DNA Primers
- DNA, Complementary
- Exons
- Genetic Variation
- Glioma
- Humans
- Intermediate Filament Proteins
- Introns
- Molecular Sequence Data