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Article

Expression of two interleukin‐15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides

1 May 1997

Abstract excerpt

Interleukin (IL)-15 is a four-helix bundle cytokine sharing several biological properties with IL-2. By reverse transcriptase-polymerase chain reaction analysis, human cancer cell lines of different histotypes are shown to express two IL-15 amplification products: a 524-bp band corresponding to the IL-15 mRNA found in macrophages, and another of 643 bp corresponding to an alternatively spliced mRNA including a...

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PMID: 9174591
DOI: 10.1002/eji.1830270502

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