Article
MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism.
Tissue antigens - 1 May 1997
Goto K, Ota M, Ohno S, Mizuki N, Ando H, Katsuyama Y, Maksymowych W P, Kimura M, Bahram S, Inoko H
Abstract excerpt
In order to address the possibility that the MICA gene located 47 kb upstream from HLA-B is involved in the pathogenesis of ankylosing spondylitis (AS), we have investigated microsatellite polymorphism in the transmembrane region of MICA in Caucasian patients with AS. The microsatellite allele consisting of 4 repetitions of GCT/AGC was present at significantly higher frequency in the patient group (Pc<0.0000001)...
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