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Article

Use of a glycerol-limited, long-term chemostat for isolation of Escherichia coli mutants with improved physiological properties.

Microbiology (Reading, England) - 1 May 1997

Weikert Christian, Sauer Uwe, Bailey James E

Abstract excerpt

The evolution of Escherichia coli MG1655 mutants was followed over 126 d in a glycerol-limited chemostat at a dilution rate of 0.05 h-1. This corresponds to a total of 217 generations at a doubling time of 13.9 h. After this time, nearly 90% of the chemostat population consisted of evolved mutant strains as determined by their altered colony morphologies on plates. Two mutants were isolated that exhibited...

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PMID: 9168607
DOI: 10.1099/00221287-143-5-1567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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