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Article

The amino-terminal module of the C4b-binding protein α-chain is crucial for C4b binding and factor I-cofactor function

15 Apr 1997

Abstract excerpt

C4b-binding protein (C4BP) regulates the classical pathway C3-convertase of the complement system. Human C4BP is composed of seven identical subunits (alpha-chains) and one unique one (beta-chain). Both types of chains contain homologous repeats called complement control proteins (CCPs); the alpha-chain contains eight CCPs and the beta-chain three. Each alpha-chain contains a binding site for C4b although the...

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PMID: 9163340
DOI: 10.1042/bj3230469

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