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Article

Mutations in alpha-chain of C4BP that selectively affect its factor I cofactor function.

The Journal of biological chemistry - 31 Oct 2003

Blom Anna M, Villoutreix Bruno O, Dahlbäck Björn

Abstract excerpt

C4b-binding protein (C4BP) inhibits all pathways of complement activation, acting as a cofactor to the serine protease factor I (FI) in the degradation of activated complement factors C4b and C3b. C4BP is a disulfide-linked polymer of seven alpha-chains and a unique beta-chain, the alpha- and beta-chains being composed of eight and three complement control protein (CCP) domains, respectively. In previous studies...

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PMID: 12893820
DOI: 10.1074/jbc.M306620200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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