[Mechanisms of bacterial resistance to beta-lactams by beta-lactamases].

Abstract excerpt

The beta-lactamases are bacterial enzymes that inactivate beta-lactam antibiotics by catalyzing the hydrolysis of the amide group of the beta-lactam ring. They are the source of much bacterial resistance to those antibiotics. Structural studies on the enzymes, i.e., penicillinases and cephalosporinases, are now well-advanced and the up-to-date knowledge of this research field were explained together with the...

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