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Article

[Development of multi-drug resistant mutants of clinical isolates of Pseudomonas aeruginosa after exposure to fluoroquinolone].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases - 1 Feb 1996

Hasegawa M, Kobayashi I, Saika T, Shimadzu M, Nishida M

Abstract excerpt

Eight multi-drug resistant mutants (4.94%) were found in 162 clinical isolates of P. aeruginosa after exposure to norfloxacin at different concentrations (1/4, 1/2, 1, 2 and 4 MICs) and were investigated for the mechanisms of drug resistance. All the mutants were eight-times more resistant to norfloxacin than the respective parents, and showed the cross-resistance to the other fluoroquinolones. However, these...

Topics

Anti-Infective Agents
Drug Resistance, Microbial
Drug Resistance, Multiple
Humans
Mutation
Norfloxacin
Pseudomonas aeruginosa

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8851384
DOI: 10.11150/kansenshogakuzasshi1970.70.123

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OMP
SDS

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