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Article

[Development of multi-drug resistant mutants of clinical isolates of Pseudomonas aeruginosa after exposure to fluoroquinolone].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases - 1 Feb 1996

Hasegawa M, Kobayashi I, Saika T, Shimadzu M, Nishida M

Abstract excerpt

Eight multi-drug resistant mutants (4.94%) were found in 162 clinical isolates of P. aeruginosa after exposure to norfloxacin at different concentrations (1/4, 1/2, 1, 2 and 4 MICs) and were investigated for the mechanisms of drug resistance. All the mutants were eight-times more resistant to norfloxacin than the respective parents, and showed the cross-resistance to the other fluoroquinolones. However, these...

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PMID: 8851384
DOI: 10.11150/kansenshogakuzasshi1970.70.123

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OMP
SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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