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Article

Exceptionally stable salt bridges in cytochrome P450cam have functional roles.

Biochemistry - 6 May 1997

Lounnas V, Wade R C

Abstract excerpt

A long-standing puzzle in structure-function studies of cytochrome P450cam is how the substrate, camphor, reaches the buried active site. The crystal structure shows no channel from the surface to the active site large enough for substrate to pass through. Recent experiments indicate that access of the rather nonpolar substrate to the active site is controlled by electrostatic interactions and may involve rupture...

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Identifiers

PMID: 9154922
DOI: 10.1021/bi9622940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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