Origin of the photoacoustic signal in cytochrome P-450cam: role of the Arg186-Asp251-Lys178 bifurcated salt bridge.

doi:10.1021/bi961508a

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Article

Origin of the photoacoustic signal in cytochrome P-450cam: role of the Arg186-Asp251-Lys178 bifurcated salt bridge.

Biochemistry - 7 Jan 1997

Di Primo C, Deprez E, Sligar S G, Hui Bon Hoa G

Abstract excerpt

The origin of the photoacoustic signal in ferrous CO-camphor-cytochrome P-450cam was investigated. Recently, the Arg186-Asp251-Lys178 bifurcated salt bridge, located above the heme pocket, has been shown to play a key role in the control of the diffusion step of camphor binding [Deprez, E., Gerbe...

Topics

Camphor
Carbon Monoxide
Chemical Phenomena
Chemistry
Cytochrome P-450 Enzyme System
Lasers
Models, Molecular
Mutagenesis, Site-Directed
Mutation
Osmolar Concentration
Pseudomonas putida
Salts
Temperature
Thermodynamics

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