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Article

Molecular analysis of the putative inactivation particle in the inactivation gate of brain type IIA Na+ channels.

The Journal of general physiology - 1 May 1997

Kellenberger S, West J W, Scheuer T, Catterall W A

Abstract excerpt

Fast Na+ channel inactivation is thought to involve binding of phenylalanine 1489 in the hydrophobic cluster IFM in L(III-IV) of the rat brain type IIA Na+ channel. We have analyzed macroscopic and single channel currents from Na+ channels with mutations within and adjacent to hydrophobic clusters in L(III-IV). Substitution of F1489 by a series of amino acids disrupted inactivation to different extents. The...

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Identifiers

PMID: 9154906
DOI: 10.1085/jgp.109.5.589
PMCID: PMC2217064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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