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Article

Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth.

Journal of periodontology - 1 Apr 1997

Dill R E, Iacopino A M

Abstract excerpt

Phenytoin is a commonly used anticonvulsant drug for the prevention of seizures. A common side effect of phenytoin (PHT) therapy is connective tissue hyperplasia, particularly in the oral cavity manifesting as gingival overgrowth. Our previous studies concerning the molecular mechanisms of drug-induced gingival overgrowth have demonstrated that PHT alters the normal tissue turnover/wound healing signal by causing...

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Identifiers

PMID: 9150043
DOI: 10.1902/jop.1997.68.4.375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth.PMID 9150043Read ↗

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