Article
Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012
Jayaraman Bhaskar, Valiathan Gopalakrishnan Mohan, Jayakumar Keerthivasan, Palaniyandi Arunmozhi, Thenumgal Siji Jacob, Ramanathan Arvind
Abstract excerpt
BACKGROUND: There have been case reports of oral squamous cell carcinoma arising from gingival overgrowth induced by phenytoin--an antiepileptic drug. However, a detailed analysis for the presence of mutations in p53 and ras genes, which are the two most frequently mutated genes in cancers, in phenytoin induced gingival overgrowth tissues has hitherto not been performed. METHODS: Cellular DNA isolated from twenty...
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