The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by <i>in vitro</i> photorepair of cyclobutane pyrimidine dimers

doi:10.1073/pnas.94.10.5255

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Article

The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by <i>in vitro</i> photorepair of cyclobutane pyrimidine dimers

13 May 1997

Abstract excerpt

Exposing skin to UVB (280-320 nm) radiation suppresses contact hypersensitivity by a mechanism that involves an alteration in the activity of cutaneous antigen-presenting cells (APC). UV-induced DNA damage appears to be an important molecular trigger for this effect. The specific target cells in the skin that sustain DNA damage relevant to the immunosuppressive effect have yet to be identified. We tested the...

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PMID: 9144224
DOI: 10.1073/pnas.94.10.5255

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