Article
A novel point mutation in the insulin gene giving rise to hyperproinsulinemia.
The Journal of clinical endocrinology and metabolism - 1 May 1997
Warren-Perry M G, Manley S E, Ostrega D, Polonsky K, Mussett S, Brown P, Turner R C
Abstract excerpt
A 58-yr-old obese white Caucasian male type 2 diabetic, entered into the UK Prospective Diabetes Study, was found to have raised fasting total proinsulin levels 708 pmol/L(-1) (normal range, 3-16 pmol/L(-1)) and normal specific plasma insulin level 29 pmol/L(-1) (normal range, 21-75 pmol/L(-1)). Immunoreactive plasma insulin, measured by RIA, was 503 pmol/L(-1). DNA was extracted, the insulin gene amplified by...
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