Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity.

doi:10.1007/s10689-016-9888-2

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Article

Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity.

Familial cancer - 1 Jul 2016

Lynch Henry T, Shaw Trudy G

Abstract excerpt

Approximately 5-10 % of cutaneous melanoma occurs in kindreds with a hereditary predisposition. Mutations in the CDKN2A gene are found to occur in approximately 20-40 % of these kindreds. The first historical mention of what is now called the familial atypical multiple mole melanoma syndrome appears to be from 1820, with more reports throughout the 1950s, 1960s, and later years. In 1991, Lynch and Fusaro...

Topics

Age Factors
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p18
Dermoscopy
Dysplastic Nevus Syndrome
Early Detection of Cancer
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation
Humans
Pancreatic Neoplasms
Pedigree
Self-Examination

Source

Open in PubMed

Identifiers

PMID: 26892865
DOI: 10.1007/s10689-016-9888-2

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