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Article

Allelic association of human dopamine D2 receptor gene in alcoholism.

JAMA - 18 Apr 1990

Blum K, Noble E P, Sheridan P J, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs A H, Cohn J B

Abstract excerpt

In a blinded experiment, we report the first allelic association of the dopamine D2 receptor gene in alcoholism. From 70 brain samples of alcoholics and nonalcoholics, DNA was digested with restriction endonucleases and probed with a clone that contained the entire 3' coding exon, the polyadenylation signal, and approximately 16.4 kilobases of noncoding 3' sequence of the human dopamine D2 receptor gene (lambda...

Topics

Alcoholism
Alleles
Brain
Chromosomes, Human, Pair 11
DNA Probes
Deoxyribonucleases, Type II Site-Specific
Female
Genetic Markers
Humans
Male
Middle Aged
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Dopamine

Receptors, Dopamine D2

Restriction Mapping

Source

Identifiers

PMID: 1969501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1969501-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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