Article
Allelic association of human dopamine D2 receptor gene in alcoholism.
JAMA - 18 Apr 1990
Blum K, Noble E P, Sheridan P J, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs A H, Cohn J B
Abstract excerpt
In a blinded experiment, we report the first allelic association of the dopamine D2 receptor gene in alcoholism. From 70 brain samples of alcoholics and nonalcoholics, DNA was digested with restriction endonucleases and probed with a clone that contained the entire 3' coding exon, the polyadenylation signal, and approximately 16.4 kilobases of noncoding 3' sequence of the human dopamine D2 receptor gene (lambda...
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