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Article

Expression of a mutant myosin light chain that cannot be phosphorylated increases paracellular permeability.

The American journal of physiology - 1 Feb 1997

Gandhi S, Lorimer D D, de Lanerolle P

Abstract excerpt

A murine leukemia retroviral vector was engineered to contain the DNA encoding either the wild-type, rat aorta 20-kDa myosin light chain (MLC20) or a mutant form of MLC20 in which Thr18 and Ser19 were mutated into alanines. These mutations result in a MLC20 that cannot be phosphorylated by myosin light chain kinase. An 11-amino acid epitope from c-myc was added to both MLC20 sequences to facilitate identification...

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Identifiers

PMID: 9124398
DOI: 10.1152/ajprenal.1997.272.2.F214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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