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Article

A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin

1 Apr 1997

Abstract excerpt

The hemophilia A mutation database lists more than 160 missense mutations: each represents a molecular defect in the FVIII molecule, resulting in the X-linked bleeding disorder hemophilia A with a clinical presentation varying from mild to severe. Without a three-dimensional FVIII structure it is in most cases impossible to explain biological dysfunction in terms of the underlying molecular pathology. However,...

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Share to Blood Coagulation and Thrombosis Mechanisms
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Identifiers

PMID: 9116285
DOI: 10.1182/blood.v89.7.2413

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A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human CeruloplasminPMID 9116285Read ↗

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