Article
Allelic and functional variability of cytochrome P4502C9.
Pharmacogenetics - 1 Feb 1997
Bhasker C R, Miners J O, Coulter S, Birkett D J
Abstract excerpt
Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp. Polymerase chain reaction (PCR)-based amplification of the nucleotide fragments encompassing the four residues (144, 358-359 and 417) in 18 samples of human genomic DNA from a liver bank...
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