Article
Dopamine D3 receptor variant and tardive dyskinesia.
European archives of psychiatry and clinical neuroscience - 1 Jan 2000
Rietschel M, Krauss H, Müller D J, Schulze T G, Knapp M, Marwinski K, Maroldt A O, Paus S, Grünhage F, Propping P, Maier W, Held T, Nöthen M M
Abstract excerpt
In the search for genetic factors contributing to tardive dyskinesia, dopamine receptor genes are considered major candidates. The dopamine D3 receptor is of primary interest as dopamine D3 receptor knock-out mice show locomotor hyperactivation resembling extrapyramidal side-effects of neuroleptic treatment. Furthermore, Steen and colleagues (1997) recently reported an association between tardive dyskinesia and a...
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