Article
Genetic association between the dopamine D3 receptor gene polymorphism (Ser9Gly) and tardive dyskinesia in patients with schizophrenia: a reevaluation in East Asian populations.
Neuroscience letters - 17 Jan 2012
Utsunomiya Kensuke, Shinkai Takahiro, Sakata Shinichi, Yamada Kenji, Chen Hsin-I, De Luca Vincenzo, Hwang Rudi, Ohmori Osamu, Nakamura Jun
Abstract excerpt
The dopamine D3 receptor gene (DRD3) is considered being one of the candidate genes contributing to the development of tardive dyskinesia (TD). In a recent meta-analysis with mixed ethnicities, only a barely positive association was found between the functional DRD3 Ser9Gly polymorphism and TD in patients with schizophrenia (OR=1.17; 95% CI: 1.01-1.37; p=0.041). To further evaluate the controversial association...
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